利水作用を有する生薬のウマ腎臓(Na<SUP>+</SUP>+K<SUP>+</SUP>)-Adenosine Triphosphataseに対する影響
書誌事項
- タイトル別名
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- The Effects of Crude Drugs Using Diuretic on Horse Kidney (Na<SUP>+</SUP>+K<SUP>+</SUP>)-Adenosine Triphosphatase
- 利水作用を有する生薬のウマ腎臓(Na++K+)-Adenosine Triphosphataseに対する影響
- リスイ サヨウ オ ユウスル ショウヤク ノ ウマ ジンゾウ Na + + K
- The effects of crude drugs using diuretics on horse kidney (Na++K+)-adenosine triphosphatase
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抄録
In the folk-medicine, several kinds of crude drugs are used as diuretics. Twenty three kinds of diuretic drugs were chosen, and examined for their effects on the horse kidney (Na++K+)-adenosine triphosphatase (ATPase), which is an intrinsic enzyme of the plasma membrane and responsible for the active transport of Na+ and K+ across the membrane. Twenty one out of twenty three kinds of ethanol extracts of diuretic drugs inhibited the kidney (Na++K+)-ATPase activity. The intensity of the inhibition of these drugs was compared by estimating the amounts of their ethanol extracts which inhibited the (Na++K+)-ATPase activity by 50% (I50, μg/ml). Among these drugs, Atractylodis Lanceae Rhizoma ( ?? ??, I50=12.8) Atractylodis Rhizoma ( ?? ??, I50=15.2), Plantaginis Semen ( ?? ?? ??, I50=16.0), Plantaginis Herba ( ?? ?? ??, I50=16.0) and Alismatis Rhizoma ( ?? ??, I50=22.0), have strong inhibitory effects on the kidney (Na++K+)-ATPase activity. The ethanol extracts of the rhizomes of Atractylodes lancea DE CANDOLLE ( ?? ?? ?? ?? ) and Atractylodis japonica KITAMURA ( ?? ?? ?? ) were examined with varying concentrations of ATP and ouabain. The mode of inhibition of these two extracts on the (Na++K+)-ATPase activity appeared to be uncompetitive with respect to ATP as judged from Line-weaver-Burk plot. The ethanol extract of Atractylodes japonica KITAMURA decreased the I50 for ouabain from 1.6×10-7 to 7.0×10-9M, while that of Atractylodes lancea DE CANDOLLE did not change the I50 for ouabain.
収録刊行物
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- 薬学雑誌
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薬学雑誌 111 (2), 138-145, 1991
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282681130481536
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- NII論文ID
- 110003649214
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 3711222
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- データソース種別
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- JaLC
- NDL
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