書誌事項
- タイトル別名
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- Preparation of Stable W/O/W Type Multiple Emulsion Containing Water-Soluble Drugs and in Vitro Evaluation of Its Drug-Releasing Properties
- スイヨウセイ ヤクブツ オ ホウガンシタ アンテイ ナ W O Wガタ フクゴ
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The stable water-in-oil-in-water (W/O/W) multiple emulsion was prepared by a two-step procedure for emulsification using glyceryl tricaprylate (Panasate-800) as the oil phase. The water-soluble drugs such as cefadroxil, cephradine, 4-aminoantipyrine, and antipyrine were selected and entrapped separately in the inner aqueous phase of W/O/W multiple emulsion. In consideration of parenteral administration, pH 7.4 phosphate buffered saline was used in both inner and outer aqueous phases. Moreover, these multiple emulsions could be significantly stable for a month at room temperature by the addition of hydrophilic polymer like gelatin and of amino acid like lysine to the inner aqueous phase.
収録刊行物
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- 薬学雑誌
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薬学雑誌 112 (1), 73-80, 1992
公益社団法人 日本薬学会
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詳細情報
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- CRID
- 1390282681130178560
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- NII論文ID
- 110003649267
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 3763782
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可