1-trans-Cinnamoyl-及び1-[trans-3-(Pyridyl)acryloyl]-2-pyrrolidinone誘導体の合成とそれらのマウスの水迷路におけるヘミコリニウム誘発学習障害に対する作用

• 長坂 達夫

• 百瀬 研一

• 浜口 文子

• 山田 健二

• 山田 博章

• 鈴木 良邦

書誌事項

タイトル別名

• Synthesis of 1-trans-Cinnamoyl- and 1-[trans-3-(Pyridyl)acryloyl]-2-pyrrolidinone Derivatives and Their Effect on Hemicholinium-Induced Impairment of Water Maze Learning in Mice
• 1-trans-Cinnamoyl-及び1-〔trans-3-(Pyridyl)acryloyl〕-2-pyrrolidinone誘導体の合成とそれらのマウスの水迷路におけるヘミコリニウム誘発学習障害に対する作用
• 1 trans Cinnamoyl オヨビ 1 trans 3 Pyridyl

抄録

Various 1-trans-cinnamoyl-2-pyrrolidinones (6a-k) and 1-[trans-3-(pyridyl)acryloyl]-2-pyrrolidinones (9a-c) were prepared as analogues of the nootropic agent, aniracetam (2), and their effects on hemicholinium-induced impairment of water maze learning in mice were examined. 1-(trans-3-Methoxycinnamoyl)-, 1-(trans-4-methoxycinnamoyl)- and 1-(trans-4-chlorocinnamoyl)-2-pyrrolidinones (6c, d, h) and 1-[trans-3-(3-pyridyl)acryloyl]-2-pyrrolidinone (9c) were found to be more active than aniracetam in these tests. In addition, these 2-pyrrolidinones (6a-k, 9a-c) were apparently observed to lengthen mouse survival time following hemicholinium injection into the brain.

収録刊行物

• 薬学雑誌

  薬学雑誌 112 (2), 100-107, 1992

  公益社団法人 日本薬学会

キーワード

• synthesis
• 2-pyrrolidinone derivative
• aniracetam
• hemicholinium-induced impairment
• water maze task
• nootropic agent

詳細情報

• CRID: 1390001206154754432
• NII論文ID: 130007277722
• NII論文ID: 110003649298
• NII書誌ID: AN00284903
• DOI: 10.1248/yakushi1947.112.2_100
• ISSN: 13475231
• ISSN: 00316903
• ISSN: http://id.crossref.org/issn/00316903
• NDL書誌ID: 3763719
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I3763719
• Web Site: https://www.jstage.jst.go.jp/article/yakushi1947/112/2/112_2_100/_pdf
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可