実験的肝障害に対する楊梅皮の防護効果(生薬学)  [in Japanese] Protective Effects of the Bark of Myrica rubra SIEB. et ZUCC. on Experimental Liver Injuries  [in Japanese]

The methanol extract from the bark of Myrica rubra SIEB. et ZUCC. showed protective effects on liver injuries induced by carbon tetrachloride(CCl_4) and α-naphthylisothiocyanate (ANIT) in rats. In this study, the fractions and some compounds from the bark of M. rubra were investigated for the protection against CCl_4 inducing liver injuries in rats. The active principles for the protection were recognized in two fractions(M-3 and M-5 Fr. 1) obtained from the methanol extract, and one of the active principles in the fraction (M-3) was found to be myricanol 5-O-β-D-(6'-O-galloyl)-glucopyranoside. In addition, these fractions protecting liver injuries induced by CCl_4 showed significant protective effects against cholestasis induced by ANIT.