コーカサス型発酵乳ケフィアの薬理活性研究(第1報)抗腫瘍活性について その1

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タイトル別名
  • Pharmacological Study on Kefir-A Fermented Milk Product in Caucasus.I. On Antitumor Activity (1)
  • コーカサス型発酵乳ケフィアの薬理活性研究-1-抗腫瘍活性について-1-
  • コーカサスガタ ハッコウニュウ ケフィア ノ ヤクリ カッセイ ケンキュウ 1

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The antitumor activity of kefir (YK-1), a fermented milk product in Caucasus, was investigated. YK-1 at oral doses of 100 or 500 mg/kg inhibited the proliferation of solid tumor of Ehrlich ascites carcinoma transplanted subcutaneously in mice. YK-1 did not show an inhibitory effect on the ear swelling induced contact dermatitis caused by picryl chloride (PC-CD). However, YK-1 inhibited the immunosuppression in Ehrlich carcinoma-bearing mice and with the freezed and dried ascites of the tumor-bearing mice containing immunosuppressive substances (EC-sup) in PC-CD-induced mice. And also, YK-1 activated the immunosuppressive activity of spleen cells of mouse treated with EC-sup. These results suggest that YK-1 may have antitumor activity against Ehrlich carcinoma and activate the immunosuppression with it.

収録刊行物

  • 薬学雑誌

    薬学雑誌 112 (7), 489-495, 1992

    公益社団法人 日本薬学会

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