1,4-Benzodiazepine系医薬品の酸性水溶液中における挙動(第9報)Flutazolamの加水分解生成物の中枢作用

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タイトル別名
  • The Behavior of 1, 4-Benzodiazepine Drugs in Acidic Media. IX. Effect of Hydrolyzate of flutazolam on the Central Nervous System
  • 1,4-Benzodiazepine系医薬品の酸性水溶液中における挙動-9-Flutazolamの加水分解生成物の中枢作用
  • 1 4 Benzodiazepineケイ イヤクヒン ノ サンセイ スイヨウエ

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抄録

Effects of hydrolizate (III·HCl) of Flutazolam (I) on the antianxiety, the anticonvulsion, the prolongation of the sleep, the muscle relaxation and the antihypoxia were compared with I in mice by the established methods. It was demonstrated that III·HCl inhibited the anxiety and pentetrazol-induced convulsion, prolonged the thiopental-induced sleep, and produced the skeletal muscle relaxation and the protection against hypobaric-hypoxia. These potencies of III·HCl were equipotent to I. These results suggested that III·HCl might be able to be delivered in an injection form.

収録刊行物

  • 薬学雑誌

    薬学雑誌 107 (10), 830-834, 1987

    公益社団法人 日本薬学会

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