キトサン膜のリゾチームによる分解と内包物質の放出

• 四方田 千佳子

• 小室 徹雄

• 木村 俊夫

書誌事項

タイトル別名

• Studies on the Degradation of Chitosan Films by Lysozyme and Release of Loaded Chemicals
• キトサン マク ノ リゾチーム ニ ヨル ブンカイ ト ナイホウ ブッシツ ノ

抄録

Chitosan films with or without chemicals of interest were prepared and degradation properties of chitosan films of themselves by lysozyme and releases of the loaded chemicals from the films were investigated. Enzymatic degradation rate of the films was dependent on the degree of deacetylation of chitosan used and decreased with an increase in its deacetylation. The acidic conditions accelerated the degradation compared to the neutral pH. Most of the water-soluble chemicals used in the present experiments except Coomassie Brilliant Blue with a strong acidic group and pullulan with a high molecular weight (5.8×10⁴-38.0×10⁴), were rapidly released from the films within 1 h. The two chemicals described above were released only in the presence of lysozyme, and their release rates were controlled by the degradation rate of the films.

収録刊行物

• 薬学雑誌

  薬学雑誌 110 (6), 442-448, 1990

  公益社団法人 日本薬学会

キーワード

• chitosan
• chitosan film
• deacetylation degree
• lysozyme
• film degradation
• film dissolution
• chemicals release

詳細情報

• CRID: 1390001206153810816
• NII論文ID: 110003650026
• NII論文ID: 130007275908
• NII書誌ID: AN00284903
• DOI: 10.1248/yakushi1947.110.6_442
• ISSN: 13475231
• ISSN: 00316903
• ISSN: http://id.crossref.org/issn/00316903
• NDL書誌ID: 3685265
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I3685265
• Web Site: https://www.jstage.jst.go.jp/article/yakushi1947/110/6/110_6_442/_pdf
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可