難溶性医薬品結晶の超微細化方法の開発に関する研究(第1報)オキソリン酸の微細化効果のポリカーボネートメンブレンろ過法による評価

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タイトル別名
  • Studies on Development of the Ultrafine Size Reduction Method of Slightly Soluble Medicinal Crystals. I. Evaluation of Size Reduction Effect for Oxolinic Acid by the Polycarbonate Membrane Filtration
  • 難溶性医薬品結晶の超微細化方法の開発に関する研究-1-オキソリン酸の微細化効果のポリカーボネートメンブレンろ過法による評価
  • ナンヨウセイ イヤクヒン ケッショウ ノ チョウ ビサイカ ホウホウ ノ カイ

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抄録

When slightly soluble medicinal crystals are administered orally, their particle size is one of the important factors affecting the bioavailability. Therefore, it was attempted to develop a new technique of particle size reduction, in which the addition of surfactants or polymers at crystallization was examined. In order to evaluate the size reduction effect for oxolinic acid (OA), the wet sieving method was studied by the use of the polycarbonate memblane filter. This method consists of the following procedures : 1) sonication of suspension more than 10 min, 2) suction filtration of suspension after dilution, 3) measurement of the weight of the residue on each filter by the determination of OA, 4) plots of the cumulative weight of residues on a log-probability paper, followed by calculation of apparent geometric mean diameter on weight basis, 5) regulation of the volume of filtrate according to the particle size of microcrystallines. It was found that the new method studied enabled to evaluate the size reduction effect easily and accurately.

収録刊行物

  • 薬学雑誌

    薬学雑誌 102 (10), 951-959, 1982

    公益社団法人 日本薬学会

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