熱電効果による麻酔下ラットの皮膚血流測定条件の検討

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タイトル別名
  • Studies on the Conditions to Measure the Dermal Blood Flow in Anesthetized Rats Using the Thermoelectrical Elements
  • 熱電効果による麻酔ラットの皮膚血流測定条件の検討
  • ネツデン コウカ ニヨル マスイ ラット ノ ヒフ ケツリュウ ソクテイ ジョ

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抄録

The experimental conditions to measure accurately the changes of dermal blood flow (DBF) in rats were studied according to the thermoelectrical element method, which was uninterfered with muscle blood flow and arteriovenous shunt in the precapillary regions. Main factors affecting the stability and the sensitivity to drugs of DBF were the body weight and the treatment to immerse into the water bath. The most suitable conditions were as follows. 1. The body weight was 245-257g. 2. The anesthetized rats were immersed into the water bath at 15°C to the depth of xiphoid process for 10 min. Under these conditions, the changes of DBF by the application of the reference drugs (norepinephrine, dl-α-tocopheryl nicotinate, inositol hexanicotinate, isoxsuprine hydrochloride) were measured accurately.

収録刊行物

  • 薬学雑誌

    薬学雑誌 103 (9), 1001-1005, 1983

    公益社団法人 日本薬学会

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