Analysis of Medicines by Coulometric Titration. III. Bromination Reaction of Sulfamethizole, Sulfamethoxypyridazine and Sulfaphenazole

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  • 電量滴定による医薬品の分析(第3報)スルファメチゾール, スルファメトキシピリダジンおよびスルファフェナゾールの臭素化反応
  • 電量滴定による医薬品の分析-3-スルファメチゾール,スルファメトキシピリダジンおよびスルファフェナゾールの臭素化反応
  • デンリョウ テキテイ ニ ヨル イヤクヒン ノ ブンセキ 3 スルファメチゾール , スルファメトキシピリダジン オヨビ スルファフェナゾール ノ シュウソカ ハンノウ

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Abstract

A conventional coulometric titration method for the determination of a small amount of Sulfamethizole, Sulfaphenazole, and Sulfamethoxypyridazine (listed in the Pharmacopoeia of Japan, 8th Ed., 1971) was examined. Sulfamethizole, Sulfaphenazole, and Sulfamethoxypyridazine were brominated quantitatively with electrolytically generated bromine, in an aqueous hydrochloric acid-potassium bromide medium. The end point was detected by a potentiometer. Sulfamethizole and sulfamethoxypyridazine reacted with 2 moles of bromine and changed to their dibromides, 2-(3, 5-dibromosulfanilamido)-5-methyl-1, 3, 4-thiadiazole and 3-(3, 5-dibromosulfanilamido)-6-methoxypyridazine, respectively, while sulfaphenazole reacted with 3 moles of bromine and changed to its tribromide, 5-(3, 5-dibromosulfanilamido)-4-bromo-1-phenylpyrazole. The brominated position of these sulfonamides was checked by infrared and nuclearmagnetic resonance spectrograms.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 93 (6), 711-716, 1973

    The Pharmaceutical Society of Japan

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