Correlation between the Physicochemical Property of Some Nonsteroidal Anti-inflammatory Drugs and Changes in Adenosine Triphosphate, Glutathione and Hemoglobin in Rat Erythrocytes

• Shimizu Makiko

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Tatsuno Masahiro

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Matsushita Reiko

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Totsuka Junko

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Inoue Yuko

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Ohta Kumiko

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Kuniya Kensuke

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Fujii Naomi

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Fukasawa Yoko

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Watanabe Nobuo

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Iwata Emiko

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Miyazaki Megumi

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Hoshino Makiko

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Onda Miho

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Matsumura Masae

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Kikuchi Yuichi

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Yamamoto Chizuru

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Hamada Masashi

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Tsuyuki Aki

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Furuta Takashi

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Kadokura Chie

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Kamiyama Yoshimi

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Kitahara Goh

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Suzuki Kayoko

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Sejima Ei

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Matsumoto Yoshiaki

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• Fukuoka Masamichi

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

Abstract

This study was conducted to explore the relationship between physicochemical property and toxic effectiveness using rat red blood cells (RBCs). The toxic effectiveness of acid nonsteroidal anti-inflammatory drugs (NSAIDs) was systemically examined by the depletion of intracorpuscular adenosine triphosphate (ATP), glutathione (GSH), and hemoglobin (Hb) at various doses, increased every 5 fmol/RBC. When the RBCs were incubated with NSAIDs, the drugs attained maximum levels within RBC, and the levels were then reduced. The ATP depletion seemed to be observed on the excretion of the drugs prior to the depletions of GSH and Hb. The physicochemical properties of NSAIDs were obtained from QMPRPlus^TM, SMILES code, and CS ChemRaw Ultra. Correlation between their physicochemical properties and their doses for the depletions of ATP, GSH and Hb was performed in comparison with those of the membrane bound enzyme (MBE) inhibiting- and methemoglobin (MHb)-generating drugs. The ATP depletion by NSAIDs was correlated with the GSH depletion and intracorpuscular levels of the drugs, but not with the Hb depletion. The GSH depletion was correlated with the Hb depletion and participated in the lipophilicity of the drugs.

Journal

• Biological and Pharmaceutical Bulletin

  Biological and Pharmaceutical Bulletin 26 (8), 1155-1165, 2003

  The Pharmaceutical Society of Japan

Keywords

• nonsteroidal anti-inflammatory drug
• adenosine triphosphate
• glutathione
• hemoglobin
• methemoglobin
• enzyme-inhibitor

Details

• CRID: 1390282679601174144
• NII Article ID: 110003655068
• NII Book ID: AA10885497
• DOI: 10.1248/bpb.26.1155
• COI: 1:STN:280:DC%2BD3sznslWgsg%3D%3D
• ISSN: 13475215
• ISSN: 09186158
• NDL BIB ID: 6620536
• PubMed: 12913268
• Web Site: http://id.ndl.go.jp/bib/6620536
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6620536
• Web Site: http://www.jstage.jst.go.jp/article/bpb/26/8/26_8_1155/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2003291215
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed