Antibacterial Activity of Extracts Prepared from Tropical and Subtropical Plants on Methicillin-Resistant Staphylococcus aureus.

• Nitta Tomoko

  Faculty of Pharmaceutical Sciences, Setsunan University

• Arai Takashi

  Faculty of Pharmaceutical Sciences, Setsunan University

• Takamatsu Hiromu

  Faculty of Pharmaceutical Sciences, Setsunan University

• Inatomi Yuka

  Faculty of Pharmaceutical Sciences, Setsunan University

• Murata Hiroko

  Faculty of Pharmaceutical Sciences, Setsunan University

• Iinuma Munekazu

  Gifu Prefectural Institute of Health and Environmental Sciences

• Tanaka Toshiyuki

  Gifu Prefectural Institute of Health and Environmental Sciences

• Ito Tetsuro

  Department of Pharmacognosy, Gifu Pharmaceutical University

• Asai Fujio

  Department of Pharmacognosy, Gifu Pharmaceutical University

• Ibrahim Iriya

  Department of Pharmacognosy, Gifu Pharmaceutical University

• Nakanishi Tsutomu

  Faculty of Pharmaceutical Sciences, Setsunan University

• Watabe Kazuhito

  Faculty of Pharmaceutical Sciences, Setsunan University

Abstract

The antibacterial activity of the extracts prepared from 181 species (75 families) of tropical and subtropical plants was screened against various types of pathogenic bacteria. Among the 505 extracts tested, 53 of them inhibited the growth of methicillin-resistant Staphylococcus aureus (MRSA). The active extracts obtained from barks of Shorea hemsleyana and roots of Cyphostemma bainessi were separated to their components, some of which greatly reduced the viable cell number of MRSA. These active compounds were all identified as stilbene derivatives. Hemsleyanol d, one of the stilbene tetramer isolated from S. hemsleyana, was the most effective compound and had MIC of 2 μg/ml.<br>

Journal

• Journal of Health Science

  Journal of Health Science 48 (3), 273-276, 2002

  The Pharmaceutical Society of Japan

Keywords

• antibacterial activity
• MRSA
• plant extract
• stilbene derivative

Details

• CRID: 1390001204498044800
• NII Article ID: 110003655110
• NII Book ID: AA11316464
• DOI: 10.1248/jhs.48.273
• COI: 1:CAS:528:DC%2BD38XkslKrs7s%3D
• ISSN: 13475207
• ISSN: 13449702
• NDL BIB ID: 6153561
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6153561
• Web Site: http://www.jstage.jst.go.jp/article/jhs/48/3/48_3_273/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2003023719
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed