ガスクロマトグラフィーによるヒト血中および尿中のベノキサプロフェングルクロン酸抱合体の定量法

• 岡本 昌二

• 藤本 恭子

• 藤友 博行

• 平井 瑛三

書誌事項

タイトル別名

• Analysis of Benoxaprofen Glucuronide in Human Plasma and Urine by Gas Chromatography
• ガス クロマトグラフィー ニヨル ヒト ケッチュウ オヨビ ニョウチュウ ノ

抄録

The main metabolite of benoxaprofen (BXP), an acidic anti-inflammatory analgesic, was isolated from human urine and identified as a glucuronide of BXP (BXP-G). BXP-G could be also detected in human blood though the amount was very slight. An improvement was attempted to the hydrolysis process in the assay method for BXP-G described by Chatfield, et al. BXP-G in urine or plasma could be rapidly and completely hydrolyzed to BXP in potassium hydroxide without any additional degradation. Thus, the present method was more accurate and less time-consuming for the assay of BXP-G than the Chatfield's method.

収録刊行物

• 薬学雑誌

  薬学雑誌 103 (1), 54-61, 1983

  公益社団法人 日本薬学会

キーワード

• benoxaprofen
• 2-(4-chlorophenyl)-α-methyl-5-benzoxazoleacetic acid
• benoxaprofen glucuronide
• 2-(3, 5-dichlorophenyl)-α-methyl-5-benzoxazoleacetic acid
• β-glucuronidase hydrolysis
• alkaline hydrolysis
• gas chromatography

詳細情報

• CRID: 1390001206128081280
• NII論文ID: 110003661064
• NII書誌ID: AN00284903
• DOI: 10.1248/yakushi1947.103.1_54
• ISSN: 13475231
• ISSN: 00316903
• NDL書誌ID: 2622705
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I2622705
• Web Site: https://www.jstage.jst.go.jp/article/yakushi1947/103/1/103_1_54/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1984011721
• データソース種別:
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  • NDL
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• 抄録ライセンスフラグ: 使用不可