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- YONEDA FUMIO
- Faculty of Pharmaceutical Sciences, Kumamoto University
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- SENGA KEITARO
- Pharmaceutical Institute, School of Medicine, Keio University
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- NISHIGAKI SADAO
- Pharmaceutical Institute, School of Medicine, Keio University
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Abstract
Reaction of a chloropyrimidine and a 5-activated pyrimidine in N-nitrosodimethylamine (NDA) resulted in the simultaneous formation of a dimethylaminopyrimidine and a 5-nitrosopyrimidine which is further transformed. A special type of Vilsmeier-Haack reaction using a mixture of NDA and phosphorus oxychloride (NDA+POCl3) for 5-activated pyrimidines has been accomplished. The reaction of 6-amino-1, 3-dimethyluracil with NDA+POCl3 under cooling gave bis (6-amino-1, 3-dimethyluracil-5-yl) methane, which was converted into 1, 3, 7, 9-tetramethyl (1H, 3H, 7H, 9H)-pyrido [2, 3-d, 6, 5-d'] dipyrimidine-2, 4, 6, 8-tetrone.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 21 (2), 260-263, 1973
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679149188480
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- NII Article ID
- 110003661948
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed