Molecular dynamics of prostaglandin F2.ALPHA.-cyclodextrin complexes in aqueous solution.

• 平山 文俊

• 上釜 兼人

• 鯉沼 秀臣

抄録

The molecular dynamics of prostaglandin F_2α (PGF_2α) and its α- and β-cyclodextrin (α- and β-CyD) complexes in aqueous solution were investigated by means of carbon-13 nuclear relaxation measurements. Some reorientation times calculated for PGF_2α in-dicated that the internal motion of the C₁₆-C₂₀ alkyl chain and the overall tumbling motion were predominantly reduced upon binding to α-and β-CyDs, respectively. Upon inclusion of PGF_2α, the internal motion of primary alcohol groups slowed down by a factor of 6 in α-CyD and by a factor of 2 in β-CyD, in comparison with the overall motions. The stability of the inclusion complexes is discussed on the basis of dynamic coupling between the molecular motions of the host and guest molecules. Dynamic coupling coefficients of 0.12 and 0.75 were obtained for the PGF_2α-α-CyD and PGF_2α-β-CyD systems, respectively, indicating a greater dynamic rigidity for the β-CyD complex as compared with the α-CyD complex. On the basis of these observations, different inclusion modes are proposed in the α- and β-CyD complexes.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 28 (7), 1975-1980, 1980

  公益社団法人 日本薬学会

キーワード

• mode of inclusion in aqueous solution

詳細情報

• CRID: 1390001204162887936
• NII論文ID: 110003662603
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.28.1975
• COI: 1:CAS:528:DyaL3cXmtlymsLk%3D
• ISSN: 13475223
• ISSN: 00092363
• ISSN: http://id.crossref.org/issn/00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/28/7/28_7_1975/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1982046191
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可