Nitrosation of 1,3-Diarylureas with Nitrosyl Chloride, Dinitrogen Trioxide and Dinitrogen Tetroxide in Dimethylformamide

• 宮原 誠

  National Institute of Hygienic Sciences

• 神谷 庄造

  National Institute of Hygienic Sciences

• 中舘 正弘

  National Institute of Hygienic Sciences

抄録

Nitrosation of 1,3-diarylureas (Ia-f) with nitrosyl chloride or dinitrogen trioxide in dimethylformamide gave 1,3-diaryl-1-nitrosoureas (IIa-f) in 59-96% yields, and nitrosation of 1,3-diarylureas (Ia, c-f) with dinitrogen tetroxide also gave 1,3-diaryl-1-nitrosoureas (IIa, c-f) in 75-91% yields. However, nitrosation of 1,3-bis (4-methoxyphenyl) urea (Ib) with dinitrogen tetroxide in dimethylformamide resulted in the formation of 1-(4-methoxy-2-nitrophenyl)-3-(4-methoxyphenyl) urea (III) in 60% yield, and nitrosation with a large excess of dinitrogen tetroxide gave 1,3-bis (4-methoxy-2-nitrophenyl) urea (IV) in 42% yield.

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 31 (1), 41-44, 1983-01-25

  公益社団法人日本薬学会

キーワード

• nitrosation
• nitration
• dinitrogen trioxide
• dinitrogen tetroxide
• nitrosyl chloride
• 1, 3-diarylurea
• 1, 3-diaryl-1-nitrosourea

詳細情報

• CRID: 1573950402199809792
• NII論文ID: 110003662661
• NII書誌ID: AA00602100
• ISSN: 00092363
• Web Site: https://search.jamas.or.jp/link/ui/1984171131
• 本文言語コード: en
• データソース種別:
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