Capillartemisin a and b, Two new choleretic principles from Artemisia capillaris herba

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By monitoring with a choleretic activity test for rat-duodenum, two new choleretic principles named capillartemisin A (1) and B (2) were isolated from Artemisiae Capillaris Herba ("Inchinko" in Japanese, the aerial part of Artemisia capillaris Thunb.), and their structures were determined on the basis of spectral evidence and by a synthesis of the methyl ester of 1 (1a). Capillartemisin A (1) and B (2) showed more potent and lasting choleretic activity than sodium dehydrocholate and the other hitherto identified choleretic principles of "Inchinko". A new flavonoid isoarcapillin (6) was also chemically elucidated.

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  • Chem. Pharm. Bull.

    Chem. Pharm. Bull. 31 352-355, 1983

    公益社団法人日本薬学会

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