Antiviral Amentoflavone from Selaginella sinensis

• MA Shuang-Cheng

  Department of Biology and Institute of Chinese Medicine, The Chinese University of Hong Kong

• BUT Paul Pui-Hay

  Department of Biology and Institute of Chinese Medicine, The Chinese University of Hong Kong

• OOI Vincent Eng-Choon

  Department of Biology and Institute of Chinese Medicine, The Chinese University of Hong Kong

• HE Yue-Hua

  Department of Biology and Institute of Chinese Medicine, The Chinese University of Hong Kong

• LEE Spencer Hon-Sun

  Departments of Microbiology and Immunology, Dalhousie University

• LEE Song-Fong

  Departments of Microbiology and Immunology, Dalhousie University

• LIN Rui-Chao

  National Institute for the Control of Pharmaceutical and Biological Products

Abstract

Amentoflavone and three other flavonoids were isolated from the ethanol extract of Selaginella sinensis. Amentoflavone showed potent antiviral activity against respiratory syncytial virus (RSV), with an IC₅₀ of 5.5 μg/ml. The contents of amentoflavone in nine species of Selaginella were determined by reversed-phase HPLC. S. sinensis showed a higher content of 1.13%.

Journal

• Biological and Pharmaceutical Bulletin

  Biological and Pharmaceutical Bulletin 24 (3), 311-312, 2001

  The Pharmaceutical Society of Japan

Keywords

• Selaginella sinensis
• amentoflavone
• anti-RSV activity
• HPLC

Details

• CRID: 1390282679603137664
• NII Article ID: 110003663388
• NII Book ID: AA10885497
• DOI: 10.1248/bpb.24.311
• COI: 1:CAS:528:DC%2BD3MXhs1Oms7Y%3D
• ISSN: 13475215
• ISSN: 09186158
• PubMed: 11256492
• Web Site: https://www.jstage.jst.go.jp/article/bpb/24/3/24_3_311/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2001141129
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed