New Norditerpenoids with Trypanocidal Activity from Vitex trifolia

• Kiuchi Fumiyuki

  Tsukuba Medicinal Plant Research Station, National Institute of Health Sciences, Japan

• Matsuo Kenji

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Ito Michiho

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Qui Tran Kim

  Research Center for Applied Chemistry, Vietnam National University

• Honda Gisho

  Graduate School of Pharmaceutical Sciences, Kyoto University

抄録

Trypanocidal constituents of the fruits of Vitex trifolia were investigated. Activity-guided isolation of the acetone extract resulted in the isolation of two new norditerpene aldehydes, 1 and 2, together with five known diterpenes: vitexifolin E (3), vitexifolin F (4), vitexilactone (5), 6-acetoxy-9-hydroxy-13(14)-labden-16,15-olide (6), and previtexilactone (7). In vitro minimum lethal concentrations of the isolated compounds against epimastigotes of Trypanosoma cruzi were 11 μM (1), 36 μM (2), 34 μM (3), 34 μM (4), 66 μM (5), 66 μM (6), and >265 μM (7).

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 52 (12), 1492-1494, 2004

  公益社団法人 日本薬学会

キーワード

• <i>Vitex trifolia</i>
• Verbenaceae
• norditerpene aldehyde
• trypanocidal constituent
• <i>Trypanosoma cruzi</i>

詳細情報

• CRID: 1390282679147460480
• NII論文ID: 110003665484
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.52.1492
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 7173514
• PubMed: 15577254
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7173514
• Web Site: http://www.jstage.jst.go.jp/article/cpb/52/12/52_12_1492/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006162487
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可