Interaction between Quaternary Ammonium Ions and Dipeptides : Positive Anion Allosteric Effect

    • ITO Kazuaki
    • Department of Chemistry and Chemical Engineering, Faculty of Engineering, Yamagata University
    • NAGASE Kayo
    • Department of Chemistry and Chemical Engineering, Faculty of Engineering, Yamagata University
    • MOROHASHI Naoya
    • Department of Chemistry and Chemical Engineering, Faculty of Engineering, Yamagata University
    • OHBA Yoshihiro
    • Department of Chemistry and Chemical Engineering, Faculty of Engineering, Yamagata University

Abstract

The binding properties of dipeptides possessing aromatic residues towards quaternary ammonium ions have been investigated by ^1H-NMR spectroscopy. The intermolecular hydrogen bonding between exchangeable protons (OH and NH) of aromatic residues of dipeptides and the counter anion of ammonium ion is the primary force. After the formation of the intermolecular hydrogen bonding, two aromatic residues of dipeptides can provide π-base cavity to interact with the quaternary ammonium moiety.

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 53(1), 90-94, 2005-01-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  15

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Cited by:  1

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Codes

  • NII Article ID (NAID) :
    110003665508
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • Article Type :
    Journal Article
  • ISSN :
    00092363
  • NDL Article ID :
    7200971
  • NDL Source Classification :
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-D167
  • DOI :
    10.1248/cpb.53.90
  • Databases :
    CJP  CJPref  NDL  NII-ELS  J-STAGE