Uptake of Gallium-67 by the Hepatocytes during Liver Regeneration in Carbon Tetrachloride-Treated Mice

• Abe Shinya

  Department of Radiopharmacy, Tohoku Pharmaceutical University

• Suyama Satoko

  Department of Radiopharmacy, Tohoku Pharmaceutical University

• Shishido Hitomi

  Department of Radiopharmacy, Tohoku Pharmaceutical University

• Sato Masayoshi

  Department of Radiopharmacy, Tohoku Pharmaceutical University

• Ohtake Yosuke

  Department of Radiopharmacy, Tohoku Pharmaceutical University

• Sato Naoko

  Department of Radiopharmacy, Tohoku Pharmaceutical University

• Ohkubo Yasuhito

  Department of Radiopharmacy, Tohoku Pharmaceutical University

抄録

Gallium-67 (⁶⁷Ga) has been used as a tumor or inflammation-imaging agent in nuclear medicine. We recently reported that the peak of serum alanine aminotransferase (ALT) level was 1 d after carbon tetrachloride (CCl₄) treatment in rats. However, the peak of ⁶⁷Ga uptake by the liver tissue and hepatocytes was 2 d after the treatment. If ⁶⁷Ga is taken in the hepatic disorder phase, the pattern of ⁶⁷Ga uptake by the hepatocytes should be consistent with that of the ALT level. In order to answer why it was not, we carried out a detailed examination. The lipid peroxidation of hepatocytes from CCl₄-treated mice was greatly increased 1 d after CCl₄ treatment; serum ALT was also increased 1 d after the treatment. The uptake of ⁶⁷Ga by the liver tissue reached a maximum 1 and 2 d after the treatment, while maximum by the hepatocytes was achieved after 2 d. The incorporation of bromodeoxyuridine into the hepatocytes also reached maximum 2 d after the treatment. These results suggest that the uptake of ⁶⁷Ga by the hepatocytes is carried out during liver regeneration rather than during hepatic disorder by CCl₄ treatment.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 27 (12), 1913-1915, 2004

  公益社団法人 日本薬学会

キーワード

• Gallium-67 (⁶⁷Ga)
• carbon tetrachloride (CCl₄)
• liver tissue
• hepatocyte
• lipid peroxidation
• bromodeoxyuridine (BrdU)

詳細情報

• CRID: 1390001204627410304
• NII論文ID: 110003665732
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.27.1913
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 7172487
• PubMed: 15577205
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7172487
• Web Site: http://www.jstage.jst.go.jp/article/bpb/27/12/27_12_1913/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006149607
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可