Effects of Ninjin-to on Levels of Calcitonin Gene-Related Peptide and Substance P in Human Plasma
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- Sato Yuhki
- Department of Clinical Pharmacy, Oita University Hospital
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- Katagiri Fumihiko
- Department of Clinical Pharmacy, Oita University Hospital
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- Inoue Shin
- Department of Clinical Pharmacy, Oita University Hospital
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- Itoh Hiroki
- Department of Clinical Pharmacy, Oita University Hospital
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- Takeyama Masaharu
- Department of Clinical Pharmacy, Oita University Hospital
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The herbal medicine Ninjin-to has been used for the treatment of gastroenteritis, esogastritis, gastric atony, gastrectasis, vomiting, and anorexia. One of the mechanisms of the empirical effects is assumed to be due to local changes in neuropeptide levels. Sensory afferent neurons in the gastrointestinal mucosa regulate neuropeptides [calcitonin gene-related peptide (CGRP), substance P, etc.], which play various physiologic roles. To determine whether the pharmacologic effects of Ninjin-to on the gastrointestine are due to changes in gastrointestinal mucosa regulatory peptide levels, we examined the effects of Ninjin-to on the levels of CGRP-like immunoreactive substances (IS) and substance P-IS in plasma taken from five healthy subjects. A single oral administration of 6.0 g of Ninjin-to caused significant increases in plasma CGRP-IS at 40 min and 60 min, and in substance P-IS levels at 90 min, compared with a placebo group. These results may indicate that the pharmacologic actions of Ninjin-to are closely related to changes in CGRP-IS and substance P-IS levels.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 27 (12), 2032-2034, 2004
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204627533440
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- NII論文ID
- 110003665754
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 7173005
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- PubMed
- 15577227
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可