クリニカルパス適用胃切除患者におけるCefazolin（CEZ）とSulbactam/Ampicillin (SBT/ABPC）の術後感染発症阻止効果並びに費用対効果の比較

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  • Comparison of the Effects of Prophylactic Antibiotic Therapy and Cost-effectiveness between Cefazolin (CEZ) and Sulbactam/Ampicillin (SBT/ABPC) in Gastric Cancer Surgery Employing Clinical Pathway
  • クリニカル パス テキヨウ イ セツジョ カンジャ ニ オケル Cefazolin CEZ ト Sulbactam Ampicillin SBT ABPC ノ ジュツゴ カンセン ハッショウ ソシ コウカ ナラビニ ヒヨウ タイ コウカ ノ ヒカク

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  The present study was designed to investigate the effects of prophylactic antibiotic therapy and the cost-effectiveness of Cefazolin (CEZ) and Sulbactam/Ampicillin (SBT/ABPC) in gastric cancer surgery employing clinical pathway. 157 patients (62 in the CEZ group and 95 in the SBT/ABPC group), who underwent surgery for gastric cancer at the First Department of Surgery of our hospital, were investigated. There was no significant difference between the groups with regard to sex, age, incidence of complication, stage of cancer, surgical method, operative time and blood loss, length of hospitalization, the appearance of systemic inflammatory response syndrome (SIRS), changes body tempreture, white blood cell count (WBC), C-reactive protein (CRP), or clinical outcome of postoperative care by a nurse during post-operation for 7 days. The prophylactic effect of infection was also no different between the CEZ (69.4%) and SBT/ABPC (69.5%) groups. In contrast, decision analysis strongly indicated that the anticipate cost of antibiotics was higher in the latter group (¥20402) than in the CEZ group (¥15556), suggesting that the prophylactic effect of CEZ may be more cost-effective. Thus, evaluations of pharmacotherapy from the aspect of cost may be one of the important responsibility of hospital pharmacists in the future.<br>

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  • 薬学雑誌

    薬学雑誌 124 (11), 815-824, 2004-11-01

    公益社団法人 日本薬学会

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