調製法の簡便さと服用性の向上を目指した院内製剤としての経口ケタミン製剤の調製と評価(1) —寒天を用いた製剤の検討—

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書誌事項

タイトル別名
  • Preparing and Evaluation of Oral Dosage Form of Ketamine Considering Simplicity for Preparation in Hospital and Ease for Patients to Take (1) —Preparations Using Agar—
  • 調製法の簡便さと服用性の向上を目指した院内製剤としての経口ケタミン製剤の調製と評価(1)寒天を用いた製剤の検討
  • チョウセイホウ ノ カンベン サ ト フクヨウセイ ノ コウジョウ オ メザシタ インナイ セイザイ ト シテ ノ ケイコウ ケタミン セイザイ ノ チョウセイ ト ヒョウカ 1 カンテン オ モチイタ セイザイ ノ ケントウ

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抄録

  Ketamine has been widely used in the operation as intravenous and intramuscular injections, since ketamine has dissociative anesthetic properties. When it is given in sub-anesthetic dose, ketamine is known to have an analgesic effect. The analgesic effect is observed for patients with neuropathic pain when administrated not only by injection but also orally. In Japan, since ketamine is not commercially available except injection forms, patients have to take it as solution of injections for the oral medication. Since the solution of injections has extremely bitter taste, patients intensely desire the development of preparations without the bitterness. In the present study, we prepared oral gel dosage forms of ketamine using agar. It is simple to prepare this dosage form, and most pharmacists can prepare it easily in many hospitals. This gel dosage form met content uniformity requirements and the shape of that was maintained intact during the dissolution test (for 10 hours). The release rate was reduced by additions of additives such as sugar and a flavor in the gel. The reason for the reduction in release could be the suppression of ketamine diffusion depended on the micro-viscosity of solution in the gel. The ketamine contents and the release profile of the gel preparations were unchanged at the room temperature for 12-week storage. The gel preparations in this study would be useful for the oral medication of ketamine, since it is easy for patients to carry them when they go out and the intensely bitter taste could be improved by the addition of a flavor.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 125 (2), 187-196, 2005-02-01

    公益社団法人 日本薬学会

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