Experimental Diabetes Model in Chick Embryos Treated with Streptozotocin

• Yoshiyama Yuji

  Division of Clinical Pharmacy, Kyoritsu University of Pharmacy

• Sugiyama Takashi

  Division of Clinical Pharmacy, Kyoritsu University of Pharmacy

• Kanke Motoko

  Division of Clinical Pharmacy, Kyoritsu University of Pharmacy

抄録

The aim of the present study was to investigate whether diabetes model can be made by treatment of streptozotocin (STZ) in chick embryos and this model can be used to predict the effect of drug. When STZ (0.3 mg/egg) was injected into the albumen of fertile eggs on the 14th day of incubation, level of blood glucose significantly increased than that of the control on the 17th day of incubation, and level of serum insulin significantly decreased. In addition, the enhanced level of blood glucose in STZ-treated embryos reduced by injection of human insulin. In conclusion, STZ-treated embryos may be applicable to evaluate human insulin and anti-diabetes drugs as an experimental diabetes model.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 28 (10), 1986-1988, 2005

  公益社団法人 日本薬学会

キーワード

• chick embryo
• streptozotocin
• diabetes
• blood glucose
• serum insulin

詳細情報

• CRID: 1390282679603356032
• NII論文ID: 110003666379
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.28.1986
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 7453185
• PubMed: 16204961
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7453185
• Web Site: http://www.jstage.jst.go.jp/article/bpb/28/10/28_10_1986/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006219895
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可