Pharmacological Study on the Novel Antinociceptive Agent, a Novel Monoterpene Alkaloid from Incarvillea sinensis

• Chi Yu-Ming

  Seiwa Pharmaceutical, Ltd.

• Nakamura Motoyuki

  Seiwa Pharmaceutical, Ltd.

• Yoshizawa Toyokichi

  Seiwa Pharmaceutical, Ltd.

• Zhao Xi-Ying

  Seiwa Pharmaceutical, Ltd.

• Yan Wen-Mei

  Beijing University of Traditional Chinese Medicine and Pharmacy

• Hashimoto Fumio

  Faculty of Pharmaceutical Sciences, Kumamoto University

• Kinjo Junei

  Faculty of Pharmaceutical Sciences, Kumamoto University

• Nohara Toshihiro

  Faculty of Pharmaceutical Sciences, Kumamoto University

• Sakurada Shinobu

抄録

To determine the antinociceptive mechanism of incarvillateine (INCA), the opiate antagonists nor-binaltorphimine (nor-BNI), β-funaltrexamine (β-FNA) and naltrindole (NTI) were pretreated prior to its injection in a formalin test. The antinociceptive effect of INCA was antagonized by nor-BNI (κ-receptor antagonist) and β-FNA (μ-receptor antagonist), while NTI (δ-receptor antagonist) did not influence its effect. Furthermore, the antinociceptive effect of INCA was blocked by theophylline (THEO), an adenosine-receptor antagonist. These results suggested that the antinociceptive effect arose from the activation of μ-, κ-receptors and adenosine-receptor.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 28 (10), 1989-1991, 2005

  公益社団法人 日本薬学会

キーワード

• monoterpene alkaloid
• incarvillateine
• antinociceptive effect
• opioid receptor
• adenosine receptor

詳細情報

• CRID: 1390282679603351936
• NII論文ID: 110003666380
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.28.1989
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 7453365
• PubMed: 16204962
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7453365
• Web Site: http://www.jstage.jst.go.jp/article/bpb/28/10/28_10_1989/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006219896
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可