Anti-inflammatory Activities of α-Truxillic Acid Derivatives and Their Monomer Components

DOI Web Site Web Site PubMed 被引用文献3件 参考文献12件

書誌事項

タイトル別名
  • Anti-inflammatory Activities of .ALPHA.-Truxillic Acid Derivatives and Their Monomer Components
  • Anti inflammatory Activities of アルファ Truxillic Acid Derivatives and Their Monomer Components

この論文をさがす

抄録

The anti-inflammatory activities of α-truxillic acid (1) and 4,4′-dihydroxy-α-truxillic acid (2) as well as their monomer components (E)-cinnamic acid (3) and (E)-p-coumaric acid (4) were evaluated in the formalin test. α-Truxillic acid (1) and its derivative 4,4′-dihydroxy-α-truxillic acid (2) exhibited significant activity against inflammatory pain response, while their monomer components (E)-cinnamic acid (3) and (E)-p-coumaric acid (4) did not show any activity against either neurogenic or inflammatory pain responses induced by formalin in mice. These results suggested that the dimeric structure might play an important role for the expression of anti-inflammatory activity. Furthermore, in order to gain information on their potencies, their anti-inflammatory activities were compared with that of incarvillateine (5) which contains the same dimeric structure and showed more potent antinociceptive activity than morphine in the formalin test. The activities of α-truxillic acid (1) and 4,4′-dihydroxy-α-truxillic acid (2) at the dose of 40 mg/kg against inflammatory pain response were equal to that of incarvillateine at doses of 20 mg/kg.

収録刊行物

被引用文献 (3)*注記

もっと見る

参考文献 (12)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ