Association between Deletion Polymorphism of Angiotensin Converting Enzyme Gene and Proteinuria in Japanese Overweight Men.
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- HASHIMOTO Yoshiaki
- Department of Clinical Laboratory Medicine, The University of Tokyo Hospital
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- FUTAMURA Azusa
- Department of Clinical Laboratory Medicine, The University of Tokyo Hospital
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- NAKARAI Hideo
- Department of Clinical Laboratory Medicine, The University of Tokyo Hospital
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- YOKOTA Hiromitsu
- Department of Clinical Laboratory Medicine, The University of Tokyo Hospital
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- OMURA Miho
- Department of Clinical Laboratory Medicine, The University of Tokyo Hospital
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- TSUKAMOTO Kazuhisa
- Departments of Internal Medicine, The University of Tokyo Hospital
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- TOGO Masako
- Departments of Internal Medicine, The University of Tokyo Hospital
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- SATO Hiroaki
- Departments of Internal Medicine, The University of Tokyo Hospital
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- HARA Masumi
- Departments of Internal Medicine, The University of Tokyo Hospital
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- Isoo Naoyuki
- Departments of Internal Medicine, The University of Tokyo Hospital
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- TAGUCHI Jun-ichi
- Departments of Internal Medicine, The University of Tokyo Hospital
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- NAKAHARA Kazuhiko
- Department of Clinical Laboratory Medicine, The University of Tokyo Hospital
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Association between Deletion Polymorphism of Angiotensin Converting Enzyme Gene and Proteinuria in Japanese Overweight Men: Yoshiaki HASHIMOTO, et al. Departments of Clinical Laboratory Medicine, The University of Tokyo Hospital—A cross-sectional study was performed in 237 overweight men (BMI: 25.0-34.8 kg/m2) to investigate the relationship between an insertion (I)/ deletion (D) polymorphism of intron 16 of the angiotensin converting enzyme (ACE) gene and proteinuria. Proteinuria (± or greater) was determined with a reagent strip. The prevalences of proteinuria were 9.2, 13.3 and 24.3% in the subjects with the ACE II, ID and DD genotype, respectively. There was a significant difference between the II and the DD genotypes in the prevalence of proteinuria. No difference among the three genotypes was observed in blood pressure, total cholesterol, HDL-cholesterol, triglycerides and HbA1C. When the subjects were divided into two groups according to the result of urinalysis, the prevalence of the DD genotype was significantly higher in the group with proteinuria (28.1 %) than in the group without it (13.7%). Multiple logistic regression analysis showed that the ACE DD genotype was independently related to proteinuria. The results suggest that the ACE DD genotype may be an independent risk factor of proteinuria in Japanese overweight men. It is specially important for subjects with the ACE DD genotype to prevent the other risk factors of proteinuria such as diabetes, hypertension and obesity by keeping healthy life-style habits. (J Occup Health 2001; 43: 80-84)
収録刊行物
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- journal of Occupational Health
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journal of Occupational Health 43 (2), 80-84, 2001
公益社団法人 日本産業衛生学会
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詳細情報 詳細情報について
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- CRID
- 1390282679430761728
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- NII論文ID
- 130003527504
- 110003723136
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- NII書誌ID
- AA11090645
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- ISSN
- 13489585
- 13419145
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- NDL書誌ID
- 5733803
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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