Ｃａｎｄｉｄａ　ａｌｂｉｃａｎｓおよびＣａｎｄｉｄａ　ｔｒｏｐｉｃａｌｉｓの特異的付着に関する研究　固定化糖による解析

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タイトル別名
  • Specific Adherence of Candida albicans and Candida tropicalis. An in vitro Study using Immobilized Sugar.
  • An<I>in vitro</I>Study using Immobilized Sugar
  • 固定化糖による解析

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To study what kinds of sugar residues are involved in the specific adherence of Candida, several kinds of sugars were coverently bound to the glass slides either by coupling p-aminophenyl-o-glycosides or amino sugars to carboxyl methylene group of glyoxylic acid conjugated glass slides, and the adherence of Candida albicans andC. tropicalisto these immobilized sugars were measured.<BR>C. albicansadhered to these glass slides with specific profiles, and the number of adherent cells were significantly higher to glass slides containing mannose-, mannosamine-, galactosamine-and fucose-residue than to control glass slides. TheC. albicansadherence to these sugar-immobilized glass was inhibited by the presence of monosaccharides with similar configuration to immobilized ones. These results, taken together, suggested that mannose-, mannosamine-, galactosamine- and fucose-residues are involved in the specific adherence ofC. albicansthrough lectinlike interaction.<BR>In contrast, C. tropicalisshowed the specific adherence only to glass slides containing glucosamine.

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