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抄録
17-エチニルエストラジオール(EE)を投与量0,0.03,0.3,1.0,3.0,10.0μg/kg/dayで3日間連続投与した20日齢の幼若ラットの子宮および膣におけるエストロゲン受容体ER-αとER-βの発現を調べた.0.3μg/kg/day以上のEE投与で子宮と膣の重量は有意に増加し,子宮に水腫が見られた.3.0μg/kg/day以上の高投与量では子宮長の増加と,肥大,ER-αとER-βの子宮管腔および腺上皮における発現の減少,腫上皮における角質化とER-αとER-βの発現の低下が見られた.これらの結果から,幼君ラットに対するEE処理は子宮と膣のER-αとER-βの発現を低下させ,これが,子宮上皮の肥大や子宮長の増加,膣の角質化に関連していると考えられた.
The action of estrogen on target organs has been actively studied with the discovery of estrogen receptor (ER) ft. This study was carried out to examine the expression of ERα and ERβ in the uterus and the vagina of immature Sprague-Dawley rats treated with 17-ethinyl estradiol (EE). Twenty days old rats were subcutaneously treated with EE at the doses of 0 (vehicle control), 0.03, 0.3, 1.0, 3.0, and 10.0 μg/kg/day for three consecutive days. The treatment of EE at the doses of 0.3, 1.0, 3.0 and 10.0 μg/kg/day significantly increased the weights of the uterus and vagina of rats (p<0.01) and retained fluid in the uterus of rats. At the high doses of 3.0 and 10.0 μg/kg/day, the treatment of EE caused an increase in the uterine height, hypertrophy, and a decrease in the expression of ERα and ERβ in the uterine luminal and glandular epithelium. The treatment of EE at the doses of 3.0 and 10.0 μg/kg/day also caused cornification and a decrease in the expression of ERα and ERβ in the vaginal epithelium. These results suggest that the EE treatment decrease the expression of ERα and ERβ in the uterus and vagina of immature rats and that may be associated with the morphological changes such as increase in the uterine height, hypertrophy of the uterine epithelium, and cornification of the vagina.
