Infection of a Chimeric Simian and Human Immunodeficiency Virus with CCR5-Specific HIV-1 Envelope to Rhesus Macaques.

• ENOSE Yoshimi

  Institute for Virus Research, Kyoto University

• MIYAKE Ariko

  Institute for Virus Research, Kyoto University

• IDO Eiji

  Institute for Virus Research, Kyoto University

• HAYAMI Masanori

  Institute for Virus Research, Kyoto University

抄録

Human immunodeficiency virus (HIV) infects lymphocytes and macrophages via CD4 and chemokine receptors. In this study, the infectivity of a chimeric simian and human immunodeficiency virus (SHIV) having a CCR5-specific HIV-1 envelope gene was examined. A SHIV strain termed SHIV-JRFL could enter cells via CD4 with a chemokine receptor CCR5, not CXCR4, and the viral replication was suppressed by recombinant human RANTES, one of β-chemokines. The intravenous inoculation of SHIV-JRFL into two rhesus macaques resulted in a systemic infection, though it was rather weak. During the early infection, the production of RANTES from Con A-stimulated PBMCs of the infected monkeys increased. These results suggested that β-chemokine has the potential to limit the infectivity of an R5-type SHIV.<br>

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 65 (2), 283-286, 2003

  公益社団法人 日本獣医学会

キーワード

• CCR5
• RANTES
• SHIV

詳細情報

• CRID: 1390282681402190080
• NII論文ID: 110003886189
• NII書誌ID: AA10796138
• DOI: 10.1292/jvms.65.283
• COI: 1:STN:280:DC%2BD3s7ktVSqtQ%3D%3D
• ISSN: 13477439
• ISSN: 09167250
• NDL書誌ID: 6477987
• PubMed: 12655130
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6477987
• Web Site: http://www.jstage.jst.go.jp/article/jvms/65/2/65_2_283/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2003159288
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可