Relation between Phenotype of Tumor Cells and Clinicopathology in Bovine Leukosis

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  • YIN Shan-ai
    United Graduate School of Veterinary Sciences, Gifu University
  • MAKARA Manami
    Department of Veterinary Pathology, Faculty of Agriculture, Iwate University
  • PAN Yaoqian
    Department of Veterinary Pathology, Faculty of Agriculture, Iwate University Department of Veterinary Pathology, University of Agriculture and Animal Science in Changchun
  • ISHIGURO Hiroyuki
    Department of Veterinary Pathology, Faculty of Agriculture, Iwate University
  • IKEDA Manabu
    United Graduate School of Veterinary Sciences, Gifu University
  • NUMAKUNAI Shigeru
    Department of Veterinary Pathology, Faculty of Agriculture, Iwate University
  • GORYO Masanobu
    United Graduate School of Veterinary Sciences, Gifu University Department of Veterinary Pathology, Faculty of Agriculture, Iwate University
  • OKADA Kosuke
    United Graduate School of Veterinary Sciences, Gifu University Department of Veterinary Pathology, Faculty of Agriculture, Iwate University

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Thirty-three cases of enzootic bovine leukosis (EBL) and 14 cases of sporadic bovine leukosis (SBL) were examined by immunohistochemistry using 6 monoclonal antibodies against leukocyte differentiation molecules of bovine leukocytes. There were 17 cases of B-1a cell type, 10 cases of B-1b cell type and 6 cases of B-2 cell type in EBL, and 5 cases originating from B cells (B-2 cell type) and 9 cases originating from immature T cells in SBL. The average age for the EBL cases of B-1a cell type was 8.6 years, B-1b cell type was 6.5 years, and of B-2 cell type was 4.5 years. In cases of SBL, immature T cell type patients were younger than B-2 cell type ones. The lymphoma originating from B cells differed from that originating from T cells in morphology. In T cell tumors, the nucleus of tumor cells was round, the edge of the cytoplasm obvious, and tumor cells were sporadically present and proliferated. When compared with T cells, the region among B cells was obscure. But, there was no relation between phenotype and the histologic classification of tumor cells. In EBL, beyond the lymph node, tumors of B-1a and B-1b types had developed in the heart and abomasum, and those of the B-2 type tended to occur in liver. In SBL, B-2 type and T type cells formed tumors in the liver, kidney, thymus, and one case of T-cell type tumor formed on the skin. We would like to propose a new classification of bovine leukosis as EBL, calf type B-cell lymphoma, juvenile T-cell lymphoma and skin type T-cell lymphoma.<br>

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