Immunohistochemical Study of Osteopontin in the Spinal Cords of Rats with Clip Compression Injury

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  • MOON Changjong
    Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National University
  • HEO Seungdam
    Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National University
  • AHN Meejung
    Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National University
  • KIM Heechul
    Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National University
  • SHIN Myungseung
    Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National University
  • SIM Ki Bum
    Department of Neurosurgery, College of Medicine, Cheju National University
  • KIM Hyung Min
    Department of Pharmacology, College of Oriental Medicine, Kyung-Hee University
  • SHIN Taekyun
    Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National University

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Expression of osteopontin (OPN) was investigated in the spinal cords of rats with clip compression injury. Western blot analysis demonstrated that OPN protein increased significantly in the spinal cord during the early stages after injury. The increased expression of OPN was partially paralleled by that of proliferating cell nuclear antigen (PCNA). Immunohistochemical staining showed that OPN was expressed in proliferating activated microglia/macrophages in core lesions and in some astrocytes at the periphery of lesions. These results indicate that expression of OPN protein increases mainly in activated microglia/macrophages after spinal cord injury, suggesting that OPN is related to cell proliferation during the early stages after injury, probably leading to tissue remodeling.<br>

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