Suppression of Glucose Absorption by Extracts from the Leaves of Gymnema inodorum.

• SHIMIZU Kazumasa

  Division of Veterinary Pharmacology, Nippon Veterinary and Animal Science University

• OZEKI Mie

  Division of Veterinary Pharmacology, Nippon Veterinary and Animal Science University

• TANAKA Katsunori

  Division of Veterinary Pharmacology, Nippon Veterinary and Animal Science University

• ITOH Kayo

  Division of Veterinary Pharmacology, Nippon Veterinary and Animal Science University

• NAKAJYO Shinjiro

  Division of Veterinary Pharmacology, Nippon Veterinary and Animal Science University

• URAKAWA Norimoto

  Division of Veterinary Pharmacology, Nippon Veterinary and Animal Science University

• ATSUCHI Mikito

  Technical Research Laboratory, Kowa Chemical Industries Co., Ltd.

書誌事項

タイトル別名

• Suppression of glucose absorption by ex

抄録

Gymnema sylvestre (GS) is one of the Asclepiad strains that grows in South-east Asia. Their therapeutic effects for treating diabetes mellitus, rheumatic arthritis and gout have been well known for a long time. However, the problem is that GS suppresses sweetness and tastes bitter. For this study, we chose Gymnema inodorum (GI) instead of GS, since it has an advantage that it does not suppress sweetness nor is it bitter in taste. In this paper, effects of glucose availability of some saponin fractions (F-I to F-IV) extracted from GI leaves, which were obtained by high-performance liquid chromatography were studied on a high K⁺-induced contraction of guinea-pig intestinal smooth muscle, O₂ consumption on guinea-pig ileum, glucose-evoked transmural potential difference (ΔPD) of guinea-pig everted intestine and blood glucose level in glucose tolerance tests on rats. The extracts of GI leaves suppressed the intestinal smooth muscle contraction, decreased the O₂ consumption, inhibited the glucose evoked-transmural potential, and prevented the blood glucose level. Our studies suggest that the component of GI inhibits the increase in the blood glucose level by interfering with the intestinal glucose absorption process.

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 59 (9), 753-757, 1997

  公益社団法人 日本獣医学会

キーワード

• glucose tolerance test
• <i>Gymnema inodorum</i> leaf
• muscle contraction
• oxygen consumption
• transmural potential

詳細情報

• CRID: 1390001206427161344
• NII論文ID: 110003915237
• NII書誌ID: AA10796138
• DOI: 10.1292/jvms.59.753
• COI: 1:STN:280:DyaK1c%2Fgt1Sruw%3D%3D
• ISSN: 13477439
• ISSN: 09167250
• NDL書誌ID: 4305185
• PubMed: 9342697
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4305185
• Web Site: http://www.jstage.jst.go.jp/article/jvms/59/9/59_9_753/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1998043985
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可