Ecabapide, a Novel Gastroprokinetic Agent, Ameliorates Gastric Emptying of Stroke-Prone Spontaneously Hypertensive Rats(SHRSP).

• FURUHAMA Kazuhisa

  Tokyo Research and Development Center, Daiichi Pharmaceutical Co., Ltd.

書誌事項

タイトル別名

• Ecabapide a novel gastroprokinetic agen

抄録

The effect of ecabapide, a novel gastroprokinetic agent, on gastric emptying was examined in stroke-prone spontaneously hypertensive rats (SHRSP), which are known to exhibit gastric malfunctions as a result of autonomic nervous system disorder. Ecabapide was administered orally to SHRSP in various dose-regimens. Gastric emptying was evaluated by the acetaminophen (APAP) method using semi-solid meal under the conscious conditions. Ecabapide significantly enhanced gastric emptying of SHRSP at 1 mg/kg in single administration, 0.3 and 1 mg/kg in 2-week treatment and 7.7 mg/kg in 4-week (diet) exposure. These results suggest that the effect of ecabapide is exerted without showing tachyphylaxis.

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 59 (12), 1153-1155, 1997

  公益社団法人 日本獣医学会

キーワード

• ecabapide
• gastric emptying
• stroke-prone spontaneously hypertensive rat (SHRSP)

詳細情報

• CRID: 1390001206427040896
• NII論文ID: 110003915317
• NII書誌ID: AA10796138
• DOI: 10.1292/jvms.59.1153
• COI: 1:CAS:528:DyaK1cXmt1KitA%3D%3D
• ISSN: 13477439
• ISSN: 09167250
• NDL書誌ID: 4368243
• PubMed: 9450247
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4368243
• Web Site: http://www.jstage.jst.go.jp/article/jvms/59/12/59_12_1153/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1998068020
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可