伝統草薬処方剤中の腎障害抑制成分の分離とマウスの実験的糸球体障害に対する抑制効果

DOI 機関リポジトリ HANDLE Web Site Web Site ほか1件をすべて表示 一部だけ表示 被引用文献2件 オープンアクセス

書誌事項

タイトル別名
  • Identification of Effective Component from a Traditional Herbal Medicine and the Inhibitory Effects on Experimental Glomerular Lesion in Mice.
  • 伝統草薬処方剤中の腎障害抑制成分の分離とマウスの実験的糸球体障害に対する抑制効果〔英文〕
  • デントウ ソウヤク ショホウザイチュウ ノ ジン ショウガイ ヨクセイ セイブ

この論文をさがす

抄録

Effective constituents for renal disease were partially purified from a herbal prescription. The efficacy on renal diseases was examined using an experimental model system of glomerular lesion in mice induced by Agkistrodon acutus venom (Ac1-P). The extract of boiling water of the herbal prescription (P-3) was first fractionated by ether into an acidic fraction and a mixture of basic and neutral fractions. The acidic fraction was proved to be more effective and then further examined by thin layer chromatography and spectrophotometry. One of the main components was confirmed to be caffeic acid which had inhibitory effect on renal failure in mice by Ac1-P. This effect was considered to be caused by caffeic acid inhibiting the proteolytic enzyme activity of Ac1-P. Caffeic acid should thus have prophylactic or inhibitory effect on glomerular disease in which proteolytic enzymes may have pathogenic roles.

収録刊行物

被引用文献 (2)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ