イヌリンパ性白血病におけるc-yes-1ガン遺伝子の増殖(短報)

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  • Amplification of a c-yes-l-Related Oncogene in Canine Lymphoid Leukemia.

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Genomic DNAs from 4 canine spontaneous lymphoid neoplasms were examined by Southern blot hybridization using 7kinds of oncogene probes. Analysis using a human c-yes-1 cDNA probe revealed amplification of the proto-oncogene in a DNA sample from a dog with lymphoid leukemia. Its degree was about 4- to 8- fold in comparison with a control DNA sample from a healthy dog. The genomic abrlormality of canine c-yes-1-related oncogene may have a role in the tumorigenesis of this neoplasm, although the significance of the structural change in this oncogene remains unclear.

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