シスプラチン惹起非乏尿性急性腎不全ラットにおける心房性ナトリウム利尿ペプチド(ANP)の腎に対する反応性

• 永野 伸郎

• 八木 幹生

• 加藤 慎一郎

• 古屋 良宏

• 宮田 そのえ

• 眞鍋 昇

書誌事項

タイトル別名

• Renal Responses to Atrial Natriuretic Peptide(ANP) in Rats with Non-Oliguric Acute Renal Failure Induced by Cisplatin.
• Renal responses to atrial natriuretic p

抄録

This study was designed to compare the renal effects of atrial (A-type) natriuretic peptide (ANP) on control (saline-injected) rats and rats with non-oliguric acute renal failure induced by cisplatin. The results obtained here are summarized as follows: (1) In the metabolic cage study, cisplatin-treated rats showed increased in blood urea nitrogen and serum creatinine while creatinine clearance decreased to the lowest levels on day 4. A transient increase in urinary protein was observed at day 4. (2) ANP infusion significantly increased urine flow fate (UFR), creatinine clearance (CCr), fractional excretion rates of sodium (FE_Na) and chloride (FE_Cl), and urinary phosphorus and magnesium (Mg) excretions in a dose-dependent manner without affecting renal plasma flow and fractional excretion rates of potassium and urea in cisplatin-treated : rats. (3) Renal effects of ANP on UFR, CCr, FE_Na, FE_Cl and excretion of Mg were more pronounced in cisplatin-treated rats compared to control rats although markedly blunted responses to ANP have been reported in nephrotic patients and nephrotic animals induced by adriamycin and aminonucleoside. (4) Histological examination showed extensive necrosis of the S₃ segment of the proximal tubule located in the outer stripe of the outer medulla with minimal glomerular abnormalities in the kidney of cisplatin-treated rats. In conclusion, the main mechanism of the increased renal responses to ANP is considered to be due to an increased delivery of sodium, fluid and ANP itself to the inner medullary collecting duct which is the major renal site of action of ANP under the condition of acute proximal tubular necrosis by cisplatin.

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 57 (6), 997-1002, 1995

  公益社団法人 日本獣医学会

キーワード

• atrial natriuretic peptide (ANP)
• cisplatin
• non-oliguric acute renal failure
• rat

詳細情報

• CRID: 1390001206425248896
• NII論文ID: 130003572216
• NII論文ID: 110003916416
• NII書誌ID: AA10796138
• DOI: 10.1292/jvms.57.997
• COI: 1:CAS:528:DyaK28XhtFyqtrw%3D
• ISSN: 13477439
• ISSN: 09167250
• ISSN: http://id.crossref.org/issn/09167250
• NDL書誌ID: 3927190
• PubMed: 8720036
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I3927190
• Web Site: http://www.jstage.jst.go.jp/article/jvms1991/57/6/57_6_997/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1996113462
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可