抄録
抗生物質による下痢の発症をウサギを用いて調べた. ウサギに各種抗生物質を静脈注射にて単回投与した結果, sulbactam/cefoperazone, cefmetazole, clindamycin, piperacillin, aspoxicillinではウサギの下痢発症率が40%以上であった. sulbactam/cefoperazoneによって下痢を起こしたウサギの盲腸内容物はClostridium difficile enterotoxin検出キットに陽性反応を示すと同時にC. difficileが分離された. 一方, cefmetazoleによって下痢を起こしたウサギについてはC. difficileとの関連は認められなかった. しかし, 下痢発症個体の腸内からはclostridiaが高い菌数で検出され, その一部はClostridium innocuumとClostridium sporogenesであった.
Rabbits were treated with a single intravenous injection of various antibiotics. More than 40 per cent of the animals showed diarrhea after being treated with sulbactam/cefoperazone, cefmetazole, clindamycin, piperacillin or aspoxicillin. Clostridium difficile was isolated from sulbactam/cefoperazone-treated diarrheic rabbits, with their cecal contents showing positive reaction in a latex agglutination test for C. diffcile enterotoxin. However, 27 cefmetazole-induced diarrheic cases were not associated with C. difficile. Other enteropathogenic bacteria, such as Campylobacter spp., Bacillus cereus, enteropathogenic Escherichia coli, coagulase positive Staphylococcus aureus, Salmonella spp., Vibrio spp., Clostridium perfringens and Clostridium spiroforme, were not isolated from either of diarrheic rabbit. However, the counts of clostridia remarkably increased in the intestine of cefmetazole-associated diarrheic rabbits. This was ascribed to the overgrowth of Clostridium innocuum and Clostridium sporogenes. There were no remarkable differences in changes in other bacterial population between diarrheic and non-diarrheic rabbits.
