マウスコロニーにおけるセンダイウイルス感染症の流行とその清浄化

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  • Outbreak and Control of Sendai Virus Infection in Mouse Breeding Colonies
  • マウス コロニー ニ オケル センダイ ウイルス カンセンショウ ノ リュウコ

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An infectious disease broke out spontaneously with high morbidity and fatality among adult and young mice in some breeding colonies of inbred and outbred strains of mice. A hemagglutinating virus was isolated from the pulmonary tissue of diseased mice and identified as Sendai virus (HVJ) by the cross HI reaction with antiserum against the isolate and known HVJ. Neither pathogenic bacteria nor mycoplasmas were detected from any organ of diseased mice. Antibodies against some other pathogenic bacteria and murine viruses were negative in the infected mouse colony. From these results, it was considered that the single infection with HVJ had caused the outbreak. There was a defference in fatality among mouse strains. Serological and epizootiological examination revealed that these colonies had been free of HVJ from 1973 to the time of outbreak in 1977. In the same animal house with those infected mouse colonies, a rat colony had already been infected with HVJ. In another animal house outbreaks of HVJ infection of mice in the past were attributed to the introduction of commercial mice. Neither reinfection nor production of HVJ antibody was evidenced in mice born after the 1977 outbreak. This is because diseased mice were eliminated from the colony during the outbreak, breeding was discontinued for nearly 2 months, and antibodies were acquired by surviving mice.

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