ラットにおける自然発生悪性線維性組織球腫由来の可移植性腫瘍の形態学的特徴

DOI 日本農学文献記事索引 Web Site Web Site PubMed 被引用文献4件

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  • Morphologic characteristics of a transplantable tumor derived from a spontaneous malignant fibrous histiocytoma in the rat.
  • ラットにおける自然発生悪性線維性組織球腫由来の可移植性腫瘍の形態学的特徴〔英文〕
  • ラット ニ オケル シゼン ハッセイ アクセイ センイセイ ソシキキュウシュ

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Malignant fibrous histiocytoma (MFH) developed spontaneously in subcutaneous tissue of the head of a 15-month-old ma1e Fischer 344 rat. The tumor was serially transplanted int6 syngeneic rats up to the 45th generation and was designated MFH-MT. Light and electron microscopic examinations revealed that the original and serially transplanted tumors were composed of an admixtute of fibroblast-like and histiocyte-like cells arranged in a storiform pattern. Neoplastic cells gave positive reactions for acid phosphatase, alkaline phosphatase, nonspecific esterase, alpha-1 antitrypsin dnd lysozyme. The tumors transplanted into the lungs and cutaneous tissue of the tail had a mixed histologic appearance of storiform, pleomorphic, myxoid and giant cell types. Moreover sclerosing hemangioma-like and osteosarcoma-like structures were also found. MFH-MT grew well in athymic nude mice showing neoplastic proliferation of pleomorphic cells strongly positive for alpha-1 antitrypsin. Development of MFH-MT was significantly retarded by the two antitumor drugs tested. The retarded tumors consisted predominantly of fibroblast-like cells and abundant collagenic fibers, whereas histiocytic cells decreased in number.

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