ネコの細胞障害性抗リンパ球抗体(Anti-F1)の作製

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タイトル別名
  • A cytotoxic antibody produced by allo-skin transplantation in cats.
  • ネコの細胞障害性抗リンパ球抗体(Anti-F1)の作製〔英文〕
  • ネコ ノ サイボウ ショウガイセイ コウ リンパキュウ コウタイ Anti-F

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A high titer of cytotoxic antibody against donor lymphocytes, tentatively designated as anti-F1, was found in one cat who received 3 times of skin allograft from the same donor. The anti-F1 antibody titer was 1:16, and the antibody activity was mostly detected in the IgG fraction. A cross-absorption test using erythrocytes from F1-positive animals revealed that the F1(+) antigen recognized by anti-F1 antibody was expressed on erythrocytes as well as lymphocytes. The frequencies of F1(+) and F1(-) types in 81 healthy cats, involving all the cats used for allo-immunization in the present study, were 30.9 and 69.1%, respectively. Moreover, F1 antigen was considered to be a hereditary antigen from family studies.

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