書誌事項
- タイトル別名
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- Heterogeneity of Hanganutziu-Deicher antigen glycoproteins in different species animal sera.
- 動物血清におけるハンガニツウ・ダイハー抗原糖蛋白の多様性〔英文〕
- ドウブツ ケッセイ ニ オケル ハンガニツウ ダイハー コウゲン トウ タンパ
- Heterogeneity of Hanganutziu-Deicher antigen glycoproteins in different species of animal sera
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抄録
A heterophilic Hanganutziu-Deicher (HD) antigen is present in many animal sera except human and chicken sera. To visualize the antigenic molecules, nine species animal and human sera were analyzed by SDS-PAGE, followed by Western blotting and immunostaining with avian anti-N-glycolylneuraminyl-lactosyl ceramide antibody which recognizes the terminal N-glycolylneuraminic acid moiety of glycoconjugates as an epitope of the HD antigen. Several HD antigen-active glycoprotein bands were detected in the sera of fetal calf, calf, horse, goat, monkey, rabbit, guinea pig, rat and mouse, except for human serum. The HD antigenic proteins showed heterogeneities in their molecular weights and were not identical with any major band visualized with silver-staining, indicating that they are minor components of serum proteins in each animal. Neuraminidase treatment destroyed the antigenicity of all proteins, confirming that N-glycolylneuraminic acid (NeuGc) at the non-reducing terminal of carbohydrate chains is the antigenic epitope in serum glycoprotein molecules as already confirmed in glycosphingolipid (GSL) antigens. The finding of HD-antigenic glycoproteins in animal sera suggests that they also stimulate HD antibody production in patients who received animal antiserum for therapeutic aim.
収録刊行物
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- 日本獸醫學雜誌(The Japanese Journal of Veterinary Science)
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日本獸醫學雜誌(The Japanese Journal of Veterinary Science) 52 (3), 567-572, 1990
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206422296704
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- NII論文ID
- 110003918231
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- NII書誌ID
- AN00191788
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- COI
- 1:CAS:528:DyaK3MXksV2m
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- ISSN
- 18811442
- 00215295
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- NDL書誌ID
- 3670938
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- PubMed
- 1696647
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可