伝染性膵臓壊死症ウイルスによるニジマスの免疫抑制

• 楯 英毅

• 児玉 洋

• 伊澤 久夫

書誌事項

タイトル別名

• Immunosuppressive effect of infectious pancreatic necrosis virus on rainbow trout (Oncorhynchus mykiss).
• 伝染性膵臓壊死症ウイルスによるニジマスの免疫抑制〔英文〕
• デンセンセイ スイゾウ エシショウ ウイルス ニ ヨル ニジマス ノ メンエキ

抄録

The infectivity of infectious pancreatic necrosis virus (IPNV) for rainbow trout (Oncorhynchus mykiss) mononuclear leukocyte subpopulations was investigated to determine the mechanisms of immunosuppression caused by the virus. IPNV was recovered from nylon wool-adherent, surface immunoglobulin (Ig)-positive leukocytes of head kidney, spleen and peripheral blood collected from virus-inoculated fish with higher titers than non-adherent, Ig-negative cells. Non-adherent cell population showed mitogenic response to phytohemagglutinin and concanavalin A but not to lipopolysaccharide. Conversely, the responses of adherent cells to these mitogens were weak. Mitogenic response and non-specific cytotoxicity of head kidney leukocytes significantly decreased by the inoculation of fish with the virus. These results suggest that the suppression of immune responses is involved in the establishment of carrier state in fish after infection with IPNV.

収録刊行物

• 日本獸醫學雜誌(The Japanese Journal of Veterinary Science)

  日本獸醫學雜誌(The Japanese Journal of Veterinary Science) 52 (5), 931-937, 1990

  公益社団法人 日本獣医学会

キーワード

• immunosuppression
• infectious pancreatic necrosis virus
• mitogenic response
• non-specific cytotoxicity
• rainbow trout.

詳細情報

• CRID: 1390282681400274048
• NII論文ID: 110003918297
• NII書誌ID: AN00191788
• DOI: 10.1292/jvms1939.52.931
• COI: 1:STN:280:DyaK3M7isVKmtw%3D%3D
• ISSN: 18811442
• ISSN: 00215295
• NDL書誌ID: 3696436
• PubMed: 2177807
• Web Site: https://agriknowledge.affrc.go.jp/RN/2030471895
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I3696436
• Web Site: http://www.jstage.jst.go.jp/article/jvms1939/52/5/52_5_931/_pdf
• 本文言語コード: en
• データソース種別:
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  • IRDB
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可