Supplementary Report on Experimental Autumn Crocus (Colchicum autumnale L.) Poisoning in Cattle: Morphological Evidence of Apoptosis

  • YAMADA Manabu
    Department of Veterinary Pathology, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan
  • MATSUI Takane
    Department of Veterinary Pathology, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan
  • KOBAYASHI Yoshiyasu
    Department of Veterinary Pathology, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan
  • FURUOKA Hidefumi
    Department of Veterinary Pathology, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan
  • HARITANI Makoto
    Tohoku Branch Laboratory, National Institute of Animal Health, Shichinohe, Kamikita-gun, Aomori 039-2586, Japan
  • KOBAYASHI Masaru
    National Institute of Animal Health, 3-1-1 Kannondai, Tsukuba, Ibaraki 305-0856, Japan
  • NAKAGAWA Michio
    Department of Veterinary Pathology, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan

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抄録

Previously we reported that tissue destruction characterized by the presence of karyopyknotic, karyorrhectic and mitotically arrested cells was seen in alimentary epithelial cells and lymphocytes in the lymphoid and hemopoietic systems of cattle experimentally administered with autumn crocus (Colchicum autumnale L.). This report deals with the mechanism of acute cellular injury following experimental autumn crocus poisoning in cattle as demonstrated by the in situ DNA strand break analysis and electron microscopy. The analyses revealed that cellular injury caused by autumn crocus was closely associated with apoptosis.

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