下垂体濾胞星状細胞と性腺刺激ホルモン産生細胞のパラクリン相互作用の調節因子としてのpituitary adenylate cyclase activating polypetide(PACAP)の役割:アクチビン-フォリスタチン制御系の調節を介して

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  • KATAYAMA Tetsuro
    Department of Veterinary Physiology, Faculty of Agriculture, Miyazaki University
  • NAKASHIMA Michiko
    Department of Veterinary Physiology, Faculty of Agriculture, Miyazaki University
  • KYAN Hisako
    Department of Veterinary Physiology, Faculty of Agriculture, Miyazaki University
  • MURAKAMI Noboru
    Department of Veterinary Physiology, Faculty of Agriculture, Miyazaki University
  • KURODA Haruto
    Department of Veterinary Physiology, Faculty of Agriculture, Miyazaki University

書誌事項

タイトル別名
  • A Role of Pituitary Adenylate Cyclase Activating Polypeptide(PACAP) as a Regulator of Paracrine Interactions between Folliculo-Stellate Cells and Gonadotropes through the Control of Activin-Follistatin Interactions.
  • role of pituitary adenylate cyclase activating polypeptide PACAP as a regulator of paracrine interactions between folliculo stellate cells and gonadotropes through the control of activin follistatin interactions

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Pituitary folliculo-stellate (FS) cells were able to modify the effect of activin-A on gonadotropes through the paracrine factor, follistatin. The present study was aimed to examine whether a hypothalamic peptide, pituitary adenylate cyclase activating polypeptide (PACAP), could be a regulator of this paracrine interaction. Co-culture of FS cell-originated cell line TtT/GF cells with rat anterior pituitary cells showed faint inhibitory effect on the stimulatory action of activin-A on FSH secretion. When PACAP was added to the culture during the co-culture period, however, the presence of TtT/GF cells caused significant suppression of the effect of activin-A on FSH secretion. Conditioned-media (CM) from TtT/GF cells, obtained by incubation of TtT/GF cells in the presence or absence of PACAP, were next added to the cultures of anterior pituitary cells alone. CM from TtT/GF cells without PACAP treatment revealed slight, but not significant, suppressive effect on activin-induced increases in FSH secretion and the percentage of FSH cells. Meanwhile, CM from PACAP-treated TtT/GF cells attenuated both effects of activin-A. Furthermore, the inhibitory effect of the CM was neutralized when follistatin antibody was present in the culture. These results suggest that PACAP is able to regulate the paracrine action of FS cells on pituitary gonadotropes. Besides expressing direct actions on pituitary endocrine cells, PACAP may have roles as a regulator of cell-to-cell interactions within the pituitary gland.

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