生化学:アポリポタンパクC-IIIは正常牛では高密度リポタンパク画分に局在するが,高脂血症牛では高密度リポタンパクよりもキロミクロンに多く検出される

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  • Increased Serum Concentration of Apolipoprotein C-III and Its Greater Distribution to Chylomicrons than to the High-Density Lipoprotein Fraction in a Calf with Hyperlipidemia.
  • Increased serum concentration of apolipoprotein C-3 and its greater distribution to chylomicrons than to the high-density lipoprotein fraction in a calf with hyperlipidemia

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A calf having extremely high concentrations of triglycerides, cholesterol and phospholipids, in particular in chylomicrons(CM)and very low−density lipoprotein(VLDL)fraction was found.The purpose of the present study was to determine serum concentration and distribution of apolipoprotein(apo)C−III, a low molecular mass protein mainly distributed in high−density lipoprotein(HDL)fraction in normolipidemic cattle, in the calf with hyperlipidemia.The serum apoC−III concentration in the calf increased to more than 10−fold that of normolipidemic control calves, and apoC−III was distributed more in the CM than in the HDL.The concentration of apoA−I(a predominant apoprotein in the HDL)was also increased to nearly 4−fold that of controls in the serum from the calf, and its major distribution site was the CM.Haptoglobin was detected in the serum from the hyperlipidemic calf, and was distributed in the CM as well as in the HDL.Serum amyloid A was also induced.In contrast to apoC−III, apoA−I and haptoglobin, the majority of apoSAA was found in the HDL fraction, as observed in normolipidemic calves.Increased concentrations in the CM of apoC−III and apoA−I suggest that the two apolipoproteins may be involved in the pathogenesis of calf hyperlipidemia.The presence of haptoglobin in the CM and HDL also implies the relevance of this acute−phase protein in the regulation of lipid metabolism.

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