Malignant Fibrous Histiocytoma(MFH) Cells and Macrophages/Histiocytes Have a Common Antigen Recognized by a Monoclonal Antibody Risen against a Rat MFH-Derived Cloned Cell Line.
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- KUMAGAI Daijiro
- Veterinary Teaching Hospital, College of Agriculture, Osaka Prefecture University
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- YAMATE Jyoji
- Department of Veterinary Pathology, College of Agriculture, Osaka Prefecture University
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- TAJIMA Tomoko
- Department of Veterinary Microbiology, College of Agriculture, Osaka Prefecture University
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- KUWAMURA Mitsuru
- Department of Veterinary Pathology, College of Agriculture, Osaka Prefecture University
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- KOTANI Takao
- Department of Veterinary Pathology, College of Agriculture, Osaka Prefecture University
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- SAKUMA Sadashige
- Department of Veterinary Pathology, College of Agriculture, Osaka Prefecture University
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Abstract
A monoclonal antibody (B9) was generated by using a rat malignant fibrous histiocytoma (MFH)-derived cloned cell line (MT-8) as the immunogen. Immunohistochemically, B9 reacted specifically with a cytoplasmic antigen of MT-8 cells. Furthermore, B9 immunolabeled another MFH-derived cloned cells (MT-9) and histiocytic sarcoma cells, as well as macrophages/histiocytes in normal and diseased tissues of rats. These findings suggest the presence of a common antigen recognized by B9 between MFH cells and macrophages/histiocytes. This suggests that MFH cells may express histiocytic nature.
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 63 (3), 333-335, 2001
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Details 詳細情報について
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- CRID
- 1390282681401655168
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- NII Article ID
- 110003920606
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- NII Book ID
- AA10796138
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- COI
- 1:CAS:528:DC%2BD3MXjtFOqt7c%3D
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- ISSN
- 13477439
- 09167250
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- NDL BIB ID
- 5715916
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- PubMed
- 11307938
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed