Cardiovascular and Renal Effects of Carvedilol in Dogs with Heart Failure.

• UECHI Masami

  Veterinary Teaching Hospital, School of Veterinary Medicine & Animal Science, Kitasato University

• SASAKI Takahiro

  Veterinary Teaching Hospital, School of Veterinary Medicine & Animal Science, Kitasato University

• UENO Kouichiro

  Veterinary Teaching Hospital, School of Veterinary Medicine & Animal Science, Kitasato University

• YAMAMOTO Taiji

  Veterinary Teaching Hospital, School of Veterinary Medicine & Animal Science, Kitasato University

• ISHIKAWA Yumi

  Veterinary Teaching Hospital, School of Veterinary Medicine & Animal Science, Kitasato University

抄録

To determine the acute effects of carvedilol (β-blocker) on cardiovascular and renal function and its pharmacokinetics in dogs. Fifteen mature mongrel dogs (7-15 kg) of both sexes were used in these experiments. Eight dogs served as controls, and seven dogs served as iatrogenic mitral regurgitation (MR) experimental animals. Carvedilol (0.2, 0.4, and 0.8 mg/kg, P.O.) was administered, and the blood carvedilol concentration was analyzed by reverse-phase high-performance liquid chromatography. The response to isoproterenol or phenylephrine was also evaluated. Isoproterenol (0.025 μg/kg/min) was infused via the saphenous vein for 5 min, and phenylephrine (5 μg/kg) was injected with carvedilol (0.2, 0.4 mg/kg) or placebo for 4 days. The heart rate and arterial blood pressure were measured, and LV fractional shortening was measured by echocardiography. Glomerular filtration rate (GFR) and renal plasma flow (RPF) were measured by intravenous infusion of sodium thiosulfate and sodium para-aminohippurate. Carvedilol (0.2 mg/kg) decreased the heart rate, whereas renal function, arterial blood pressure, and left ventricular contractile function were not affected. Carvedilol (0.4 mg/kg) decreased heart rate, blood pressure, and renal function. The tachycardic response to isoproterenol was significantly diminished for 36 hr by 0.4 mg/kg carvedilol. Carvedilol 0.2 mg/kg inhibited this effect for 24 hr. Thus, it is necessary to titrate the dosage of carvedilol, it should be initiated at less than 0.2 mg/kg and titrated up to 0.4 mg/kg for heart failure dogs.

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 64 (6), 469-475, 2002

  公益社団法人 日本獣医学会

キーワード

• β-blocker
• heart failure
• hemodynamics
• mitral regurgitation
• renal function

詳細情報

• CRID: 1390001206425505024
• NII論文ID: 110003920879
• NII書誌ID: AA10796138
• DOI: 10.1292/jvms.64.469
• COI: 1:CAS:528:DC%2BD38XlvVSmtbc%3D
• ISSN: 13477439
• ISSN: 09167250
• NDL書誌ID: 6200431
• PubMed: 12130829
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6200431
• Web Site: http://www.jstage.jst.go.jp/article/jvms/64/6/64_6_469/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2003053654
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可