A Comparative Pathological Study on Canine Necrotizing Meningoencephalitis and Granulomatous Meningoencephalomyelitis
-
- SUZUKI Mari
- Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University
-
- UCHIDA Kazuyuki
- Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University
-
- MOROZUMI Motoji
- Togasaki Animal Hospital
-
- HASEGAWA Takashi
- Department of Veterinary Teaching Hospital, Faculty of Agriculture, Miyazaki University
-
- YANAI Tokuma
- Department of Veterinary Pathology, Faculty of Agriculture, Gifu University
-
- NAKAYAMA Hiroyuki
- Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
-
- TATEYAMA Susumu
- Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University
書誌事項
- タイトル別名
-
- Comparative Pathological Study on Canine Necrotizing Meningoencephalitis and Granulomatous Meningoencephalomyelitis
この論文をさがす
抄録
Canine necrotizing meningoencephalitis (NME) and granulomatous meningoencephalomyelitis (GME) were compared pathologically. Gross observation exhibited lateral ventricular dilation and discoloration, malacia and/or cavitation of the cerebrum in NME. On the contrary, gross changes were milder in GME, except for occasional visible granulomatous mass formation. Histopathologically, the lesions of NME were distributed predominantly in the cerebral cortex and various degrees of inflammatory and necrotic changes were observed according to clinical stages. Besides, microscopic lesions of GME were mainly distributed in the white matter of the cerebrum, cerebellum and brainstem, which are characterized by perivascular cuffing, multiple granulomas and leptomeningeal infiltrates. Although macrophages and lymphocytes were predominant in the inflammatory lesions of both disorders, macrophages in GME transformed into epithelioid cells and exhibited more massive infiltration. Although lectin RCA-1-reactive cells were numerous in both disorders, lysozyme immunoreactive cells in NME were fewer than that in GME. Parenchymal infiltration of MAC387-positive cells was common in GME and limited in NME. The number of CD3-positive lymphocytes in the GME lesions tended to be greater than in NME, though the difference was not statistically significant. Morphological and immunohistochemical differences of the lesions, in particular, the characteristics of infiltrative macrophages may reflect these different pathogeneses of the two disorders.<br>
収録刊行物
-
- The Journal of Veterinary Medical Science
-
The Journal of Veterinary Medical Science 65 (11), 1233-1239, 2003
公益社団法人 日本獣医学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001206425829760
-
- NII論文ID
- 110003920987
-
- NII書誌ID
- AA10796138
-
- ISSN
- 13477439
- 09167250
-
- NDL書誌ID
- 6927103
-
- PubMed
- 14665754
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可